Selected
publications

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Englund JI, Bui H., Paavolainen O., Dinc D., McKenna T., Laitinen S., Munne P., Klefström J., Peuhu E., Katajisto P., “Laminin Matrix Adhesion Regulates Basal Mammary Epithelial Cell Identity“  Journal of Cell Science, 135, 23, 15 p., jcs260232. (2022)

Ritchie A., Laitinen S., Katajisto P., Englund JI., “ Tonga”: A Novel Toolbox for Straightforward Bioimage Analysis”Frontiers in Computer Science 4:777458. doi: 10.3389/fcomp.2022.777458 (2022)

Döhla J., Kuuluvainen E., Gebert N., Amaral A., Englund JI., Gopalakrishnan S., Konovalova S., Nieminen AI., Salminen ES., Torregosa Munumer R., Ahlqvist K., Yang Y., Bui H., Otonkoski T., Käkelä R., Hietakangas V., Tyynismaa H., Ori A., Katajisto P. ”Metabolic determination of cell fate through selective inheritance of mitochondria” Nature Cell Biology, Feb;24(2):148-154 (2022)

Pentinmikko N., Lozano R., Andrersson S., Scharaw S., Englund JI., Castillo-Azofeifa D, Gallagher A., Broberg M., Song K-Y., Sola Carvajal A., Speidel T., Sundstrom M., Allbritton N., Stevens M., Klein O., Teixera A., Katajisto P. ”Cellular shape reinforces niche to stem cell signaling in the small intestine” Science Advances, 8, 41, p. eabm184 (2022)

Englund JI, Ritchie A., Blaas L., Cojoc, H., Pentinmikko N., Döhla J., Iqbal S., Patarroyo M., Katajisto P., ”Laminin alpha 5 Regulates Mammary Gland Remodeling Through Luminal Cell Differentiation and Wnt4 Mediated Epithelial Crosstalk” Development  Jun 15;148(12):dev199281  (2021)

Flanagan DJ., Pentinmikko N., Luopajärvi K., Willis NJ., Gilroy K., Raven A., Mcgarry L., Englund JI, Webb A., Scharaw S., Nasreddin N., Hodder MC., Ridgway RA., Minnee E., Romagnolo B., Perret C., Williams AC., Clevers H., Sphyris N., Gilchrist E., Najumudeen AK., Lähde M., Alitalo K., Clark W., Nixon C., Kirschner K., Jone YE., RistimäkiA., Leedham S., Fish PV., Vincent JP., Katajisto P., Sansom O. ”Notum inhibits local Wnt signalling to increase the competitiveness of Apc-mutant clones” Nature  Jun;594(7863):430-43 (2021)

Tervonen TA., Pant SM., Belitškin D., Englund JI, Närhi K, Haglund C, Kovanen PE, Verschuren EW, Klefström J. "Oncogenic Ras disrupts epithelial integrity by activating the transmembrane serine protease hepsin” Cancer Res, Mar 15;81(6):1513-1527   (2021). 

Belitskin D, Pant S, Munne P, Suleymanova I, Belitškina K, Ala-Hongisto H, Englund JI, Raatikainen T, Klezovitch O, Vasioukhin V, Li S, Wu Q, Monni O, Kuure S, Laakkonen P, Pouwels J, Tervonen TA., Klefström J. ”Hepsin regulates TGFβ signaling via fibronectin proteolysis” EMBO Reports,  Nov 4;22(11):e52532 (2021)

Marques, E., Englund JI, T. A. Tervonen, E. Virkunen, M. Laakso, M. Myllynen, A. Makela, M. Ahvenainen, T. Lepikhova, O. Monni, S. Hautaniemi and J. Klefstrom. "Par6g Suppresses Cell Proliferation and Is Targeted by Loss-of-Function Mutations in Multiple Cancers." Oncogene,  Mar 17;35(11):1386-98 (2015).

Tervonen, T. A., D. Belitskin, S. M. Pant, Englund JI, E. Marques, H. Ala-Hongisto, L. Nevalaita, H. Sihto, P. Heikkila, M. Leidenius, K. Hewitson, M. Ramachandra, A. Moilanen, H. Joensuu, P. E. Kovanen, A. Poso and J. Klefstrom. "Deregulated Hepsin Protease Activity Confers Oncogenicity by Concomitantly Augmenting Hgf/Met Signalling and Disrupting Epithelial Cohesion." Oncogene,  Apr 7;35(14):1832-46 (2015).

Partanen JI., T. A. Tervonen, M. Myllynen, E. Lind, M. Imai, P. Katajisto, G. J. Dijkgraaf, P. E. Kovanen, T. P. Makela, Z. Werb and J. Klefstrom. "Tumor Suppressor Function of Liver Kinase B1 (Lkb1) Is Linked to Regulation of Epithelial Integrity." Proc Natl Acad Sci U S A 109, no. 7 (2012): E388-97. 

Partanen JI., A. I. Nieminen, T. P. Makela and J. Klefstrom. "Suppression of Oncogenic Properties of C-Myc by Lkb1-Controlled Epithelial Organization." Proc Natl Acad Sci U S A 104, no. 37 (2007): 14694-9 

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Review articles

Lan Q, Satta J, Myllymäki S-M, Trela E, Lindström R, Kaczynska B, Englund JI,  and  ML Mikkola “Protocol for Studying Embryonic Mammary Gland Branching” Morphogenesis Ex VivoMethods Molecular Biology, Vol. 2471, Mammary Stem Cells, Chapter 1 (2021)

Koledova Z, Howard BA, Englund JI, Bach K, Bentires-Alj M, Gonzalez-Suarez E. ”European Network of Breast Development and Cancer turned 10 years: a growing family of mammary gland researchers”. Breast Cancer Res no 20 (2018):102

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Preprints

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Englund JI, Cojoc, H., Blaas L., Ritchie A., Pentinmikko N., Döhla J., Iqbal S., Munne P., Patarroyo M., Klefstrom J., Ivaska J., Katajisto P., ”Laminin alpha 5 is Necessary for Mammary Epithelial Growth and Function by Maintaining Luminal Epithelial Cell Identity” BioRxiv (2019)